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2 edition of Regulation of mucus secretion by cells isolated from the rat gastric mucosa. found in the catalog.

Regulation of mucus secretion by cells isolated from the rat gastric mucosa.

Andrew Clive Keates

Regulation of mucus secretion by cells isolated from the rat gastric mucosa.

by Andrew Clive Keates

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Published by Aston University. Department of Pharmaceutical Sciences in Birmingham .
Written in


Edition Notes

Thesis (PhD) - Aston University, 1991.

ID Numbers
Open LibraryOL13907481M

  cAMP and Secretagogue Interactions in Isolated Gastric Glands Feed-back Mechanism Systems between the ATP-adenylate Cyclase-cAMP and ATP-Na+—K+-dependent ATP-ase-ADP in the Rat and Human Gastric Fundic Mucosa in Relation to Gastric Acid Secretion Peptidergic Regulation of the Cyclic AMP System in the Intestinal EpitheliumBook Edition: 1. and adaption to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis ; landin on acid secretion or the gastric circulation. the prevention of gross lesions in the gastric mucosa.

The third volume in The Gastrointestinal System reflects the expansion of knowledge of the cell physiology of secretion. Each chapter, grouped by traditional anatomical location, was written emphasizing the cellular bases of secretion and includes a review of the broader as well as the more integrative aspects of secretion. a reduction of parietal and chief cells in the body mucosa essentially12l. The histopathology in the gastric mucosa of this type of gastritis is similar to that in the gastric mucosa of patients with pernicious ane­ mia and A type atrophic gastritis. In addition to these morphological findings, as a high.

secretion of DGL and of gastric mucus. This obser- vation led to the present investigation of the cellu- lar localization of DGL using immunofluorescence techniques. Results showed that DGL is cytolocal- ized in mucous pit cells of gastric glands. Pepsino- gen is found in chief cells. To the authors’ knowl-. Other articles where Gastric mucosa is discussed: human digestive system: Gastric mucosa: The inner surface of the stomach is lined by a mucous membrane known as the gastric mucosa. The mucosa is always covered by a layer of thick mucus that is secreted by tall columnar epithelial cells. Gastric mucus is a glycoprotein that serves.


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Regulation of mucus secretion by cells isolated from the rat gastric mucosa by Andrew Clive Keates Download PDF EPUB FB2

J Physiol. Apr; Regulation of mucus secretion by cells isolated from the rat gastric mucosa. Keates AC(1), Hanson PJ. Author information: (1)Division of Cited by: The present study was undertaken to investigate the biochemical mechanisms underlying the action of PGE2 on mucus production in the rat gastric mucosa.

Whole rat gastric mucosa and isolated gastric cells were used for studying the effects of PGEZ, cAMP and inhibitors of RNA and protein synthesis on acid and mucus by:   Biochemical mechanisms of regulation of mucus secretion by prostaglandin E2 in rat gastric mucosa. Bersimbaev RI, Tairov MM, Salganik RI.

The effects of prostaglandin E2 (PGE2) and inhibitors of RNA and protein synthesis on rat gastric mucosa were investigated in order to study the cellular and biochemical mechanisms involved in the PGE2 Cited by: They allow for a massive increase in numbers of mucus-producing cells without replacing surface ciliated cells.

Active secretion of Cl(-) and HCO3 (-) by serous cells produces most of the fluid of. Intrinsic Factor (IF) secretion was studied using isolated gastric mucosal cells from rat and man. In the rat, IF was localized to the chief cells and its secretion responded most efficaciously to carbachol.

DbcAMP and hexoprenaline were less powerful, whereas histamine and pentagastrin lacked any effect. In man, IF secretion derived from the parietal cells and was increasingly enhanced by Cited by: 5.

Parietal cells, which secrete hydrochloric acid (HCl) are scattered in the glands, with most of them in the middle part. The upper part of the glands consist of mucous neck cells; in this part the dividing cells are seen. The pyloric glands contain mucus-secreting cells.

Several types of endocrine cells are found in throughout the gastric : Pfeiffer A, Rochlitz H, Noelke B, Tacke R, Moser U, Mutschler E, Lambrecht G () Muscarinic receptors mediating acid secretion in isolated rat gastric parietal cells are of M3 type.

Gastroenterology – PubMed CrossRef Google ScholarCited by: 8. We examined the effects of the gastrin family of peptides on gastric mucus glycoprotein (mucin) biosynthesis in rat gastric mucosa using an organ culture technique. Radiolabeled mucin was obtained from the tissue and culture medium of the corpus and antrum of rat stomach incubated for 5 hr with [ 3 H]glucosamine (GlcN).Cited by: gastric and duodenal mucosa (Huang et al, ).These studies suggest that gastric mucus content, increase in gastric mucous cells count could contribute significantly to maintaining normal gastric integrity.

In this study, actions of L-citrulline on gastric mucous secretion and mucus cell count is evaluated. Method Drug Preparation. Gastric mucosa. The inner surface of the stomach is lined by a mucous membrane known as the gastric mucosa.

The mucosa is always covered by a layer of thick mucus that is secreted by tall columnar epithelial cells. Gastric mucus is a glycoprotein that serves two purposes: the lubrication of food masses in order to facilitate movement within the stomach and the formation of a protective layer.

Mucus-producing cells of the mammalian gastric mucosa are classified mainly as surface mucus or gland mucus cells (Fig.

2) and respective mucins differ in their peptide sequences and chemical composition of the carbohydrate moieties. The core peptides of the mucins from the surface and gland mucus cells of the human stomach are characterized as Cited by: 5.

IT is a matter of debate whether histamine in the gastric mucosa acts as a local chemical mediator for other gastric stimulants, and the isolated bullfrog mucosa provides a convenient model for Author: Andrea Todisco. Download Membrane bound Atp dependent Energy Systems and the Gastrointestinal Mucosal Damage and Protection Download free online book chm pdf Direct Action of Helicobacter pylori on the Freshly Isolated Rat Gastric Mucosa Cells.

is the accidental passing of solid or liquid stool or mucus from the rectum. This book provides a brief. The book makes an insight into the assessment of premalignant lesions, current management of early gastric cancer, risk and protective factors in gastric carcinogenesis.

The book describes the role of different diagnostic tools in the preoperative assessment of patients and the most important factors contributing to the prognosis. Define mucous secretion. mucous secretion synonyms, mucous secretion pronunciation, mucous secretion translation, English dictionary definition of mucous secretion.

Noun 1. mucous secretion - protective secretion of the mucus membranes; in the gut it lubricates the passage of food and protects the epithelial cells; in Mucous secretion. In this article we will discuss about the structure of gastric mucosa.

The gastric mucosa is normally covered by a thick layer of mucous. Once this layer is removed, one can make out a number of pores known as gastric pits. Each pit is the out let for gastric glands (Fig.

The gastric glands are tubular glands which extend from the. The products of the endocrine cells are secreted directly into the bloodstream and are not a part of the gastric juice. The endocrine cells secrete the hormone gastrin, which functions in the regulation of gastric activity. Regulation of Gastric Secretions.

The regulation of gastric secretion is accomplished through neural and hormonal mechanisms. Gastric mucosa is a layer of the stomach composed of epithelium, lamina propria, and muscularis epithelium covers the surface of the gastric mucosa and consists of a single layer of columnar cells that secrete a thick, slippery, clear fluid called mucus as well as an alkaline fluid.

Mucus and alkaline fluid provide protection to the epithelium from mechanical injury and gastric acid. Background: Studies on the regulation of gastric and pancreatic secretion began more than years ago. Secretin was the first hormone postulated to exist, initiating the field of endocrinology.

Gastrin produced in the antral mucosa was the second postulated hormone, and together with histamine and acetylcholine, represent the three major gastric acid secretagogues known since Cited by: 4.

Gastric Mucosa; Gastric Epithelium: Throughout the stomach, the areas of the gastric epithelium which face the lumen of the stomach produce substantial amounts of mucus which covers the gastric wall and offers protection from the digestive gastric juice.

The gastric epithelium also forms large invaginations into the Lamina Propria, creating gastric glands which are described in the next section. gastric acid secretion phase. vagal stimulation mediates secretion during the gastric phase but the stimulus is derived from distension of the stomach.

Additionally, protein products in the stomach further induce acid secretion. If the pH falls below 1 in the stomach, acid secretion is inhibited by feedback regulation of gastric D cells by H+.The gastric mucosal barrier requires adequate secretion of mucus and bicarbonate, as well as: A) adequate blood flow to the gastric mucosa.

B) secretion of hydrochloric acid by the parietal cells. C) the release of calcium from gastric smooth muscle. D) contraction of gastric smooth muscle.On one hand, the main effect is associated to anti-inflammatory response due to PG and NO inhibition; on the other hand, PG is responsible for the integrity of gastric mucosa through activation of a cascade of mechanisms that include inhibition of gastric acid secretion, stimulation of mucus-bicarbonate secretion and apoptosis, as well as Cited by: 4.